No-Needle Mesotherapy vs. Micro-Needle Mesotherapy – Which Is More Effective?
Source: The purpose of the study is to identify the anti-aging effects of vitamin C with needle and no-needle mesotherapy.
Background:
 In simple words, the epidermis (the outer layer of the skin) is protected by a water and lipid layer. Vitamin C antioxidants help protect the skin from damage and minimize the effect of aging caused by sun exposure. Techniques like no-needle mesotherapy and micro-needle mesotherapy are used to enhance the absorption of different active ingredients in the skin and enhance the penetration of beneficial substances.
Method:
To study the effectiveness of needleless and needle mesotherapy, 17 healthy volunteers received four treatments. They received 2.5ml of serum from strawberries that contained 20% L-ascorbic acid and hydrate. The procedure was performed on one-half of the face with no-needle mesotherapy, and the same function was performed with micro-needle mesotherapy.
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No-Needle Mesotherapy vs. Micro-Needle Mesotherapy:
| Aspect | No-Needle Mesotherapy | Micro-Needle Mesotherapy |
| Method | A non-invasive technique using electric pulses, electroporation, and ultrasounds to enhance penetration of active ingredients. | It Involves controlled puncturing of the skin with fine needles to create micro-channels for enhanced absorption of active ingredients. |
| Invasiveness | Non-invasive. | Minimally invasive. |
| Procedure | This procedure is typically painless and does not involve needles penetrating the skin. | It involves the use of fine needles that puncture the skin. |
| Mechanism of Action | No-needle mesotherapy enhances penetration of active ingredients through the skin’s barrier using physical factors. | Micro-needle mesotherapy creates micro-injuries in the skin, stimulating collagen production and facilitating deeper penetration of active ingredients. |
| Recovery Time | The recovery time period for needleless mesotherapy is minimal to none. | It may involve a short recovery time depending on the intensity of treatment. |
| Suitability for Concerns | Needle-less mesotherapy is suitable for various skin concerns including hydration, rejuvenation, and anti-aging. | Micro-needle mesotherapy is particularly beneficial for improving fine lines, wrinkles, scars, and overall skin texture. |
| Frequency of Treatments | It requires multiple sessions for optimal results. | In micro-needle mesotherapy, multiple sessions may be required for optimal results. |
| Professional Supervision | It is performed by skincare professionals. | It is only performed by trained professionals such as dermatologists or licensed estheticians. |
| Cost | No-needle mesotherapy is generally less expensive compared to micro-needle mesotherapy. | It may be more expensive due to the specialized equipment and technique required. |
| Side Effects/Risks | Minimal risk of side effects such as redness or irritation are involved in no-needle mesotherapy. | In needle mesotherapy possible side effects include redness, swelling, and temporary discomfort depending on the intensity of treatment. |
 Conclusion:
The techniques, No-Needle Mesotherapy and Micro-Needle Mesotherapy were found effective, but micro-needle mesotherapy shows much effectiveness in terms of improving skin elasticity, firmness, hydration, and skin tone as compared to no-needle mesotherapy.
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